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KMID : 0043320110340060901
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Archives of Pharmacal Research
2011 Volume.34 No. 6 p.901 ~ p.905
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Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27
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Ren Hong
Liu Wei wei
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Abstract
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A new cell cycle inhibitor, nidurufin (1), was isolated from the marine-derived fungus Penicillium flavidorsum SHK1-27. An evaluation of antitumor activity indicated that 1 induced in vitro cell cycle arrest at G2/M transition in the K562 cell line in a concentration and timedependent manner, with an IC50 value of 12.6 M.
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KEYWORD
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Penicillium flavidorsum SHK1-27, Nidurufin, Cytotoxicity, Cell cycle inhibitor
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